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3.2 Destruction of periodontal soft tissues The integrity and function of PDLFs, essential for softtissue homeostasis, are compromised by ferroptosis through a twofold assault on collagen: synthesis is reduced because PDLF viability and activity are impaired, while degradation is accelerated by ferroptosisassociated ROS and proinflammatory mediators ( in vitro primary cell models, indicate that ferroptosis in periodontal ligament fibroblasts serves as an active driver of soft tissue destruction

Summary Keywords IGF-1 signaling, microRNAs, aging, aging-related disease, therapeutic agents Citation Jung HJ and Suh Y (2015) Regulation of IGF -1 signaling by microRNAs

Neurochem Res 2009

Rheinstdter and Mouritsen, 2013b